Fri Nov 22 2024

58 articles - From Friday Nov 15 2024 to Friday Nov 22 2024

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Inflamm Bowel Dis

Comment on: "The Burden of Psychiatric Manifestations in Inflammatory Bowel Diseases: A Systematic Review With Meta-analysis".

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J Crohns Colitis

Partial Enteral Nutrition in the Management of Crohn's Disease: A Systematic Review and Meta-Analysis.

Partial enteral nutrition may help in various aspects of CD management but much of the current evidence is of low quality. Well-designed RCTs are required to confirm findings from current literature and before clinical recommendations can be made.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Association of dietary choline intake with incidence of dementia, Alzheimer's disease and mild cognitive impairment: a large population-based prospective cohort study.

In conclusion, our findings suggest that moderate dietary choline intake, ranging from 332.89 mg/d to 353.93 mg/d, is associated with lower odds of dementia and better cognitive performance.

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Associations between dietary fibers and gut microbiome composition in the EDIA longitudinal infant cohort.

Introducing complementary dietary fibers during the weaning period supports gut microbiome diversification and stabilization. Even minor dietary variations showed significant associations with microbial taxa and functions from the onset of weaning, highlighting the importance of infant dietary recommendations that support the gut microbiome maturation during early life. Clinical trial registration

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Associations of alcohol intake with gut microbiome: a prospective study in a predominantly low-income Black/African American population.

We identified gut microbial taxa associated with habitual alcohol intake among Black/African American males, although the magnitudes of these associations were generally small. Further research is needed to determine if these bacteria modify alcohol-disease relationships.

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Changes in fatty acid intake and subsequent risk of all-cause and cause-specific mortality in males and females: a prospective cohort study.

These findings support replacing SFA with unsaturated fatty acids (especially from plant sources) and eliminating dietary TFA to reduce premature death.

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Content of Selected Nutrients and Potential Contaminants in Prenatal Multivitamins and Minerals: an Observational Study.

Current PMVM labels are misleading with the potential to harm pregnant persons and fetuses through omission or inaccurate content of essential nutrients and inclusion of heavy metals. Regulation is needed, and the Food and Drug Administration needs sufficient authority and staffing to oversee these dietary supplements.

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Effect of a 12-month intervention with whey protein powder on cognitive function in older adults with mild cognitive impairment: a randomized controlled trial.

Supplementation with whey protein powder rich in MFGM, taurine, and B vitamins for 12-month improved cognitive function in older adults with MCI.

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Produce prescription benefits redemption and activity in an observational study of 2,680 Massachusetts Medicaid members.

Activity and redemption can each be high in PRx, and may be positively associated with more shopping locations, longer participation and program implementation experience, and specific participant demographic factors. These findings inform interpretation of prior and design of future research on PRx, health outcomes, and health care utilization.

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Proteomic analysis identifies novel biological pathways that may link dietary quality to type 2 diabetes risk: evidence from African American and Asian cohorts.

Our study across geographically and ethnically diverse populations identified robust protein biomarkers for healthy dietary patterns. Furthermore, our findings suggest novel biological mechanisms linking dietary patterns with type 2 diabetes development.

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School-based nutrition education programs alone are not cost-effective for preventing childhood obesity: A microsimulation study.

SNAP-Ed-endorsed nutrition education curricula alone are unlikely to be cost-effective for preventing childhood obesity. Continued efforts to implement interventions with strong evidence for effectiveness, including PSE approaches, are needed.

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The prospective associations of fetal growth-related pregnancy complications with subsequent breastfeeding duration and markers of human milk production.

Individuals with HDP and those with SGA infants tend to breastfeed for a shorter duration; however, only HDP appeared to be associated with biomarkers of compromised milk production. Further research and support are needed to help individuals with HDP and SGA achieve their breastfeeding goals. This study was registered as NCT01174875, and can be accessed at

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Inflamm Bowel Dis

Biologics and Oral Small Molecules Are Not Associated With Increased Major Adverse Cardiovascular Events or Venous Thromboembolism in Inflammatory Bowel Disease.

Inflammatory bowel disease patients treated with biologics or OSM were not at increased risk of MACE or VTE. Although further studies and longer follow-up periods are needed to confirm these findings, our results provide reassurance regarding the safety of these medications in IBD.

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Factors Associated With Biologic Therapy After Ileal Pouch-Anal Anastomosis in Patients With Ulcerative Colitis.

Several demographic, disease-related, surgery-related, and genetic factors associated with post-IPAA biologic therapy were identified. Physicians treating patients with UC undergoing colectomy should incorporate these factors into their decision-making process. These patients may benefit from closer postoperative follow-up, and earlier initiation of biologic therapy should be considered.

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Fecal Myeloperoxidase Levels Reflect Disease Activity in Children With Crohn's Disease.

Fecal myeloperoxidase may be superior to fCal at reflecting disease severity in children with CD and produces the damaging oxidant hypochlorous acid during active inflammation.

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Long-Term Course and Prognostic Factors in Pediatric Ulcerative Proctitis: A Multicenter Cohort Study.

The typical initial treatment of pediatric UP was 5-ASA suppositories, despite poor compliance. Biologics or other immunosuppressive treatments were needed in 37% of patients. Close follow-up with adjustment of treatment should be considered in children with UP as its clinical course varies.

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Myosteatosis Evaluated Based on Intramuscular Adipose Tissue Content Is a Risk Factor for Postoperative Complications in Crohn's Disease.

This study established IMAC as a valuable marker for sarcopenic obesity and predicting postoperative complications in patients with Crohn's disease. Furthermore, evaluating myosteatosis using IMAC will facilitate the decision of the optimal timing of surgery, prediction of complications, and treatment of sarcopenia in patients with Crohn's disease.

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The Bidirectional Relationship Between Sleep and Pain in Crohn's Disease: A Daily Diary Study.

Sleep continuity and abdominal pain are closely related, with sleep efficiency, total sleep time, and sleep quality potentially driving next-day abdominal pain. As interventions for pain in IBD are limited, it may be important to capitalize on the impact of sleep disturbances on pain to optimize overall wellbeing in people with CD.

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The Risk of Venous Thromboembolism in Children With Inflammatory Bowel Disease.

This study confirms the increased risk of VTE in children with IBD compared with children without IBD. The time of greatest VTE risk was around diagnosis. Cerebral venous sinus thrombosis was significantly more common in children with IBD than other children.

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Why Symptoms Linger in Quiescent Crohn's Disease: Investigating the Impact of Sulfidogenic Microbes and Sulfur Metabolic Pathways.

Microbial-derived sulfur pathways and downstream mitochondrial function are perturbed in qCD + S, which implicate H2S signaling in the pathogenesis of this condition. Future studies will determine whether targeting H2S pathways results in improved quality of life in qCD + S.

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J Crohns Colitis

Development and Validation of a Sexual Quality of Life Score for Youths with Inflammatory Bowel Disease.

BLOOMI score is a new validated score to assess the sexual QoL in 15-25 years with IBD. This tool may improve the screening for sexual challenges encountered by youths with IBD and may support future research into the impact of IBD on young patients' lives.

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Fatigue in patients with inflammatory bowel disease in remission one year after diagnosis (the IBSEN III study).

Stricter definitions of disease remission were not associated with a decreased likelihood of fatigue. For patients in endoscopic/radiological remission, CF was independently associated with sleep disturbances and current treatment with infliximab.

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Impact Of Hladqa1*05 And Hladqa1*03 On Safety And Loss Of Response To Anti-Tnf In Patients With Inflammatory Bowel Disease.

HLADQA1*05 is associated with a higher risk of LOR and immunogenicity, particularly to infliximab. HLADQA1*03 seems to play a protective role against LOR, particularly to adalimumab. Female sex and infliximab are risk factors for AE.

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Incidence, disease burden and clinical presentation of patients newly diagnosed with inflammatory bowel disease in a population-based inception cohort.

We found a high incidence of IBD in Copenhagen with a substantial disease burden characterized by early and high requirement for advanced therapies and high rates of fatigue, disability and impaired HRQoL at diagnosis.

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Low Incidence of Macular Edema and Other Ocular Events in the Etrasimod Development Program.

Macular edema and other ocular events were uncommon in patients treated with etrasimod across multiple conditions. Incidence of Macular edema was comparable with placebo.

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Use of MM-SES-CD Endoscopic Improvement Thresholds Enhances Effect Size Differentiation between Adalimumab vs. Placebo: A Post-hoc Analysis of the EXTEND Trial.

MM-SES-CD definitions improved discrimination between treatment and placebo and offered superior predictive accuracy for week 52 ER. Its use may enhance trial efficiency and better predict long-term disease outcomes.

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Liver Transpl

Jehovah's Witnesses: Challenges in liver disease management and in liver transplantation.

There remains a paucity of data on disparities in liver care and outcomes in patients of the Jehovah's Witnesses faith. Future research on liver diseases and liver transplantation in Jehovah's Witnesses should focus on creating registries of patient outcomes and centers with experience.

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Pre-transplant metabolic tumor volume predicts recurrence following liver transplantation for colorectal metastasis: A multicenter study.

and relevance PET-MTV ≥70 cm3 was associated with reduced RFS and OS after LT for CRLM, confirming findings from the Norway group. This is likely due to its' ability to identify residual viable tumors, which are independently associated with recurrence. PET-MTV should be a key selection criterion prior to LT for CRLM.

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Smoking and outcomes in candidates for Liver Transplantation: Analysis of the pulmonary vascular complications of liver disease 2 (PVCLD2).

Patients with advanced liver disease undergoing evaluation for LT who smoke have an increased risk of death. Smoking cessation could lead to improved overall survival with or without LT.

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Tobacco use, cirrhosis, and age are predictors of readiness to change and continued drinking following brief alcohol intervention in Veterans.

Overall, we found that in a large cohort of Veterans seen in hepatology clinics that in routine practice,a brief intervention targeted at alcohol use is feasible. Older patients with concomitant tobacco use, cirrhosis, and anxiety may need more longitudinal attention to ensure that the initial interest in reducing problem drinking is sustained.

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Utilization of biomarkers for alcohol use in liver transplantation candidates with alcohol-associated liver disease.

A minority of ALD patients provided a positive urine EtG in the pre-transplant phase. Alongside clinical interview, biomarker testing is an objective tool to identify ongoing alcohol use in ALD patients.

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Pancreatology

An improved invagination pancreaticojejunostomy technique associated with a lower incidence of pancreatic fistula: A single-center study.

The improved invagination PJ technique reduces the incidence of CR-POPF and improves prognosis.

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Ca<sup>2+</sup> signaling of pancreatic acinar cells in malignant hyperthermia susceptibility.

These results suggest that the Y522S RyR1 mutation alter the Ca 2+ -homeostasis in PACs, but not as much as to cause or aggravate AP.

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Next-generation sequencing improves diagnostic accuracy of imaging and carcinoembryonic antigen alone for pancreatic cystic neoplasms.

NGS analysis of pancreatic cyst fluid demonstrates high specificity and may serve as an additional diagnostic tool to CEA. Combining cystic fluid CEA and NGS increases the accuracy in determining whether a lesion is mucinous and NGS showed a higher diagnostic accuracy in advanced lesions compared to CEA. While the absence of alarming NGS findings should not preclude surgical treatment, patients with alarming mutations should be considered for surgery.

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Outcomes of percutaneous versus endoscopic transmural necrosectomy for necrotizing pancreatitis: A propensity score-matched study.

In real world setting, sicker patients tend to be more effectively managed through PEN compared to ETN. PEN demonstrates comparable efficacy and safety to ETN in the treatment of NP patients.

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Pancreatic atrophy is a predictor for exocrine pancreatic dysfunction: Data from a large cohort of patients with chronic pancreatitis.

We conclude that following the suggested cutoffs, pancreatic atrophy in CP is independently associated with EPD.

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The combined effect of hypoxia activation and radiosensitization by a multifunctional nanoplatform system enhances the therapeutic efficacy of chemoradiotherapy in pancreatic cancer.

The nanoplatform had a good targeting effect and synergistic anti-tumor effect. The combination of hypoxia activation and radiotherapy sensitization is a promising strategy for the treatment of pancreatic cancer.

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Utilization of relative evaluation of pancreatic perfusion CT parameters to support appropriate pancreatic adenocarcinoma diagnosis.

Relative evaluation of PCT parameters is expected to contribute to more appropriate diagnosis of PAC.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Inflamm Bowel Dis

Enhancing Gut Microbiome Research for Inflammatory Bowel Diseases Therapy: Addressing Study Limitations and Advancing Clinical Translation.

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Letter to the Editors.

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Stricturing Crohn's Disease: When Biologics May Help or Not?

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Pancreatology

Early detection of pancreatic cancer: Study design and analytical considerations in biomarker discovery and early phase validation studies.

Multisite and multidisciplinary collaboration can facilitate study design strategies in this lethal but low incidence disease and streamline the path from biomarker discovery to clinical use. Improvements in analytical and experimental design methods could help accelerate biomarker evaluation through the phases of biomarker development.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

J Crohns Colitis

Association of the HLA DQA1*05 allelic gene variants with immunogenicity to anti-TNF therapeutics - important differences between infliximab and adalimumab.

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Liver Transpl

Fellows' Corner.

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Issue Information - Author Checklist.

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Issue Information - Author Checklist.

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Issue Information - Instructions to Authors.

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Issue Information - Instructions to Authors.

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Issue Information.

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Issue Information.

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Issue Information.

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Issue Information.

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Issue Information.

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Mapping new mechanisms: Hypothermic oxygenated perfusion attenuates the immune response after human liver transplantation.

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Risk of bleeding after percutaneous liver procedures in patients with cirrhosis: myth or fact?

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

Improving the dietaryindex R Package: A Proposal to Include Additional Components for More Accurate DII Computation in NHANES.

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Pancreatology

Exploring the role of neoadjuvant therapy for resectable pancreatic cancer.

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